2. Apoptosis
  3. Apoptosis
  4. Lirentelimab

Lirentelimab  (Synonyms: 莱瑞利单抗; AK002; Anti-Siglec-8 Reference Antibody (lirentelimab))

目录号: HY-P99371 纯度: 99.91%
COA

摩尔计算器

Lirentelimab (AK002) 是一种人源化 IgG1 单克隆抗体，靶向唾液酸结合的 Ig 样凝集素 8 (SIGLEC8)。Lirentelimab 诱导 IL-5 激活的嗜酸性粒细胞细胞凋亡并抑制 IL-5 介导的肥大细胞激活。Lirentelimab 可用于嗜酸性胃炎、十二指肠炎的研究。

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CAS No. : 2283348-97-8

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规格 价格 是否有货 数量
1 mg ￥3000
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5 mg ￥7800
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Lirentelimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Lirentelimab 的抗原结合片段 (fab) 与重组 SIGLEC8 胞外结构域 (ECD) 的亲和力为 464 pM[1]。
Lirentelimab 对体外表达的 SIGLEC8、嗜酸性粒细胞上表达的 SIGLEC8 以及人血中通过其 Fc 域表达的 NK 细胞具有高亲和力[1]。
Lirentelimab (1 µg/mL) 选择性地结合人外周血中的嗜酸性粒细胞，以及人肺组织中的嗜酸性粒细胞和肥大细胞[1]。
Lirentelimab (0.0001-100 μg/mL；30 min) 诱导 IL-5 激活的嗜酸性粒细胞凋亡[1]。
Lirentelimab (30 min) 对健康供者外周血白细胞 (PBL) 制剂中嗜酸性粒细胞的 EC50 值为 1.9 ng/mL 并产生抗体依赖的细胞毒性 (ADCC)[1]。
Lirentelimab 降低离体人体组织中嗜酸性粒细胞数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lirentelimab 相关抗体:

Apoptosis Analysis[1]

Cell Line: Eosinophils
Concentration: 10 μg/mL-1 pg/mL
Incubation Time: 30 min
Result: Dose-dependently induced apoptosis of IL-5-activated (50 ng/mL) eosinophils.
体内研究
(In Vivo)

Lirentelimab (100 μg；静脉注射，一次) 在系统性过敏反应小鼠模型中显著抑制 IgE 介导的肥大细胞激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Humanized mice (NSG-SGM3) engrafts with human thymus, liver, and HSC[1]
Dosage: 100 μg
Administration: Intravenous injection; 100 μg, once
Result: Completely prevented passive systemic anaphylaxis (PSA) as shown by a lack of change in rectal temperature and symptom scores in mice.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

莱瑞利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Lirentelimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lirentelimab2283348-97-8AK002 Anti-Siglec-8 Reference Antibody (lirentelimab)莱瑞利单抗AK 002AK-002Apoptosismonoclonal antibodyapoptosiseosinophilmast cellduodenitiseosinophilic gastritishuman bloodADCCInhibitorinhibitorinhibit

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